Simpler Grants.gov #RFA-NS-26-030

NIH NINDS Solicits Research Projects for Genomic and Biologic Therapies for ADRD

The National Institutes of Health (NIH), through the National Institute of Neurological Disorders and Stroke (NINDS), is soliciting research proposals for the development of genomic and biologic therapies targeting Alzheimer’s Disease-Related Dementias (ADRD). - Government Buyer: - National Institutes of Health (NIH) - National Institute of Neurological Disorders and Stroke (NINDS) - Products/Services Requested: - Research projects focused on optimizing and translating genomic and biologic therapeutic candidates for ADRD - Targeted conditions include frontotemporal degeneration (FTD), Lewy body dementia (LBD), and vascular contributions to cognitive impairment and dementia (VCID) - Activities may include: - Therapeutic design refinement and manufacturability - Pharmacology, toxicology, and biodistribution studies - In vivo efficacy testing - Regulatory data generation and IND submissions - First-in-human clinical studies (if applicable) - Unique/Notable Requirements: - Emphasis on disease-modifying therapies for ADRD - Projects must align with ADRD Summit priorities - Open to a wide range of applicants: nonprofits, tribal organizations, government entities, educational institutions, and for-profit businesses - Funding instrument is a cooperative agreement - Approximately $6,000,000 in total funding with about three awards anticipated - No specific OEMs or vendors are named, as this is a research grant opportunity.

Description

The National Institutes of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects proposing the optimization and translational development of genomic and biologic therapeutic candidates for Alzheimer’s Disease-Related Dementias (ADRD). The program supports projects across the translational pipeline, from optimization through IND development and early clinical evaluation, for genomic and biologic therapeutic candidates with compelling preclinical evidence. Applications are not being solicited at this time, but notice is provided for potential applicants to develop collaborations and projects.

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