Simpler Grants.gov #PAR-25-037

NIH Research Grant for Cellular and Molecular Biology of Complex Brain Disorders (R21)

This opportunity from the National Institutes of Health (NIH) invites applications for research grants focused on the cellular and molecular biology of complex brain disorders. - Government Buyer: - National Institutes of Health (NIH), a federal agency - Products/Services Requested: - Research services investigating high confidence risk factors and neural function in complex brain disorders - Emphasis on intracellular, transcellular, and circuit substrates using in vivo, in situ, or in vitro experimental paradigms - Use of model organisms or human cell-based assays is permitted - Dissemination of research findings to federated data resources is required - Unique or Notable Requirements: - No clinical trials allowed under this opportunity - Focus on early stage, high-risk, exploratory, or proof-of-concept studies with little or no preliminary data - Research must contribute to common data resources - No specific OEMs or vendors are named, as this is a research grant rather than a product procurement

Description

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high confidence risk factors associated with complex brain disorders, focusing on intracellular, transcellular, and circuit substrates of neural function. Studies may be hypothesis-generating or hypothesis-testing and utilize in vivo, in situ, or in vitro experimental paradigms, including model organisms or human cell-based assays. The research aims to elucidate the neurobiological impact of individual or combined risk factors and disseminate findings to enrich common data resources. This NOFO supports early stage, high-risk, exploratory approaches or proof-of-concept studies with little or no preliminary data.

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