Opportunity

Simpler Grants.gov #RFA-NS-26-009

NIH COMBINE Initiative: Collaborative Neuroscience Research Grant Opportunity (RM1 Clinical Trial Optional)

Buyer

National Institutes of Health

Posted

August 28, 2025

Respond By

June 23, 2026

Identifier

RFA-NS-26-009

NAICS

541715

The National Institutes of Health (NIH), through the National Institute of Neurological Disorders and Stroke (NINDS), is preparing a Notice of Funding Opportunity (NOFO) for collaborative neuroscience research grants under the COMBINE initiative (RM1 Clinical Trial Optional). - Government Buyer: - National Institutes of Health (NIH) - National Institute of Neurological Disorders and Stroke (NINDS) - Opportunity Details: - Funding for highly-integrated, multidisciplinary research teams (3-6 principal investigators) - Focus on a single, ambitious goal that addresses major barriers, challenges existing paradigms, or develops new foundational principles in neuroscience - Research must significantly advance the NINDS mission within five years - Projects may range from basic neuroscience to translational research impacting human health - Eligibility: - Open to government agencies, nonprofits, educational institutions, businesses, and foreign institutions - Notable Requirements: - Emphasis on innovative, cross-disciplinary collaboration - Projects must demonstrate coordination and integration beyond traditional grant mechanisms - No OEMs, vendors, or specific products/services are mentioned, as this is a research grant opportunity

Description

The National Institute of Neurological Disorders and Stroke (NINDS) is soliciting applications from highly-integrated transdisciplinary team science led by 3-6 PDs/PIs to pursue a single focused goal to overcome persistent barriers, challenge orthodoxies, achieve paradigm-shifts, or develop new foundational principles in neuroscience. The team must deliver outcomes within five years that significantly advance the NINDS mission and transform knowledge and practice, ranging from fundamental neuroscience to human health. The research should require an innovative convergence of disciplines beyond traditional grant mechanisms. Applications are not currently being solicited; this notice allows potential applicants time to develop collaborations and responsive projects.

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