Opportunity

Simpler Grants.gov #PAR-25-446

NIH Grant for Research on Interventions for Substance Use Disorders and Overdose

Buyer

National Institutes of Health

Posted

September 10, 2025

Respond By

August 21, 2028

Identifier

PAR-25-446

NAICS

541715, 541720

This opportunity from the National Institutes of Health (NIH) seeks grant applications for research on interventions to prevent and treat substance use disorders (SUDs) and overdose. - Government Buyer: - National Institutes of Health (NIH) - Part of the Drug Use and Addiction Research Programs (Assistance Listing 93.279) - Scope of Research: - Supports discovery and development of interventions for SUDs and overdose - Includes both preclinical and clinical studies - Focus on advancing candidate interventions (medications and medical devices) toward regulatory approval or clinical adoption - Interventions may address co-morbid SUDs - Eligibility: - Open to government agencies, nonprofits, businesses, educational institutions, tribal organizations, and foreign entities - Clinical trials are optional - Funding Details: - Maximum award amount: $3,000,000 - No cost sharing or matching required - Notable Requirements: - Broad eligibility for applicants - No specific OEMs, vendors, products, or part numbers are named - Utilizes the UG3/UH3 activity code

Description

This Funding Opportunity Announcement (NOFO) from the National Institutes of Health solicits grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose. The research includes preclinical and clinical studies aimed at advancing candidate interventions closer to regulatory approval or clinical adoption. The NOFO utilizes the UG3/UH3 activity code and supports development of medications and medical devices to treat co-morbid SUDs. Eligible applicants include government entities, nonprofits, businesses, educational institutions, and other organizations.

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