Simpler Grants.gov #PAR-26-095

NIH Grant for In Vivo Chemical Probe Discovery for Brain Targets

This opportunity from the National Institutes of Health (NIH), led by the National Institute on Aging (NIA), seeks research proposals for the discovery of in vivo chemical probes for novel brain targets. - Government Buyer: - National Institutes of Health (NIH) - National Institute on Aging (NIA) - Collaborating Institutes: National Eye Institute (NEI), National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH) - Products/Services Requested: - Research and development services focused on discovering and optimizing small molecule chemical probes for brain targets - Projects must start with validated hit compounds and include bioassays for testing new analogs - Emphasis on understanding biological processes and validating targets relevant to brain disease mechanisms - Unique/Notable Requirements: - Proposals should provide new insights into disease-related biological targets and processes - Collaboration across multiple NIH institutes is anticipated - No specific OEMs, vendors, or commercial products are named, as this is a research grant opportunity - Funding opportunity number: PAR-26-095 - Assistance listing: 93.866 (Aging Research)

Description

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to support investigators interested in discovering in vivo chemical probes for novel brain targets. Collaborations are expected with the National Eye Institute (NEI), the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH). Applicants should have starting compounds (validated hits) for chemical optimization and bioassays for testing new analogs. The NIH aims to stimulate research in discovery and development of small molecules for understanding biological processes relevant to NEI, NIDA, NIMH, and NIA, and discovery and validation of biological targets informing brain disease mechanisms. Projects providing new insights into disease-related biological targets and processes are prioritized.

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