Simpler Grants.gov #RFA-HL-26-026

NIH HeartShare 2.0 Clinical Trial and Clinical Centers Research Grant Forecast

The National Institutes of Health (NIH), through the National Heart, Lung, and Blood Institute (NHLBI), is forecasting a funding opportunity for the HeartShare 2.0 program to advance research on heart failure with preserved ejection fraction (HFpEF). - Government Buyer: - National Institutes of Health (NIH) - National Heart, Lung, and Blood Institute (NHLBI) - Opportunity Overview: - Forecasted Notice of Funding Opportunity (NOFO) for establishing: - One Clinical Trial Center (CTC) - Up to seven Clinical Centers (CCs) - Scope of Work: - Clinical Trial Center (CTC): - Coordinate precision clinical trial activities for HFpEF - Develop master protocols, manage projects, oversee recruitment, monitor performance milestones, and ensure scientific conduct of trials - Clinical Centers (CCs): - Recruit and retain heart failure patients and controls - Conduct deep phenotyping protocols and obtain tissue biopsies - Support future clinical trials - Application Details: - Applicants may apply for either the CTC or a CC - Each application must specify the center type in the project title - A companion NOFO will support a Data Translation Center for overall program coordination - Unique Requirements: - Demonstrated expertise in HFpEF, deep phenotyping, and clinical trial management - No specific products, OEMs, or vendors are named, as this is a research grant opportunity - No purchase quantities or part numbers specified - Notable Aspects: - Focus on research infrastructure and clinical trial coordination rather than procurement of goods or commercial services

Description

The National Heart, Lung, and Blood Institute (NHLBI) plans to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) under the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including protocol development and trial management. The CCs will recruit and retain heart failure patients and controls, conduct deep phenotyping protocols, obtain tissue biopsies, and support future clinical trials. Eligible applicants may submit proposals for either the CTC or CC, with each application including the respective designation in the project title. This notice is to allow potential applicants time to prepare; applications are not currently being solicited.

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