Simpler Grants.gov #PAR-25-442

NIH Grant for Research on Undruggable Disease Targets

This opportunity invites research organizations to apply for NIH funding to explore new approaches for targeting undruggable classes in human diseases. - Government Buyer: - National Institutes of Health (NIH) is the sole agency involved - OEMs and Vendors: - No specific Original Equipment Manufacturers (OEMs) or vendors are named, as this is a research grant - Products/Services Requested: - No products or specific services are being procured - The opportunity funds exploratory and early-stage research projects proposing innovative methods or agents to modulate disease targets not addressable by current therapeutic types - Unique or Notable Requirements: - Open to a wide range of applicants, including nonprofits, government entities, businesses, and educational institutions - Non-domestic entities and components are not eligible - Clinical trials are excluded from this funding opportunity - No cost sharing or matching is required

Description

This Notice of Funding Opportunity (NOFO) solicits applications for exploratory and early-stage projects targeting undruggable target classes within intractable human diseases. Applicants must identify a human disease relevant undruggable target class and develop selective methods or agents for these targets. The goal is to advance innovative strategies to modulate targets not addressable by established therapeutic types, promoting the development of selective methods and agents for undruggable target classes. The funding is provided as a grant with no cost sharing or matching requirement. The opportunity is open to a wide range of applicants including nonprofits, government entities, businesses, and educational institutions.

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