Simpler Grants.gov #RFA-TR-25-002

NIH Grant for Preclinical Proof of Concept Studies in Rare Diseases

This opportunity from the National Institutes of Health (NIH), through the National Center for Advancing Translational Sciences, provides grant funding for preclinical proof of concept studies targeting rare diseases. - Government Buyer: - National Institutes of Health (NIH) - National Center for Advancing Translational Sciences - Products/Services Requested: - Preclinical efficacy studies in established rare disease models - Includes pharmacodynamic and pharmacokinetic investigations - Focus on small molecules, biologics, and biotechnology-derived products - Unique/Notable Requirements: - Supports demonstration that a therapeutic agent warrants further development - Aims to advance projects toward IND application or clinical trials, including repurposing/repositioning - No specific OEMs or vendors named; opportunity is for research and development - Eligible applicants: educational institutions, government agencies, nonprofits, and businesses - No cost sharing or matching required - Funding instrument is a grant - OEMs: - No OEMs specified, as the focus is on research and development of therapeutic agents - Place of Performance: - National Institutes of Health (federal office)

Description

This notice of funding opportunity (NOFO) provides funding to conduct efficacy studies in an established rare disease preclinical model to demonstrate that a proposed therapeutic agent warrants further development. It supports preclinical efficacy, pharmacodynamic, and pharmacokinetic studies for therapeutic agents including small molecules, biologics, or biotechnology-derived products. The goal is to advance projects to attract subsequent investment for full Investigational New Drug (IND) application development or progression to clinical trials in cases of repurposing or repositioning. Eligible applicants include a wide range of educational institutions, government entities, nonprofits, and businesses. The funding instrument type is a grant, and there is no cost sharing or matching requirement.

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