Simpler Grants.gov #PAR-25-210

NIH Solicitation for Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

The National Institutes of Health (NIH) is seeking applications for innovative mechanistic research to advance precision probiotic therapies. - Government Buyer: - National Institutes of Health (NIH) - Eligible Applicants: - Educational institutions, government entities, nonprofits, and businesses - Products/Services Requested: - Mechanistic research projects focused on precision probiotic interventions - Studies to characterize person-specific biological features influencing probiotic responses - Research using animal models or human subjects to identify subgroups of responders and improve clinical outcomes - Unique or Notable Requirements: - No specific OEMs or vendors are named, as this is a research grant opportunity - Applicants must provide supportive preliminary data - Use of innovative models to test causality or predictability of host biological patterns - Research areas include complementary and integrative health, oral diseases, aging, women's health, and cancer cause and prevention

Description

This notice of funding opportunity (NOFO) supports highly innovative mechanistic research to accelerate precision probiotic interventions. It solicits R33 applications to characterize person-specific features affecting probiotic responses to identify subgroups of responders and enhance clinical outcomes. The goal is to understand and develop strategies to address barriers in precision probiotic therapies caused by human heterogeneity. Studies should assess unique host biology patterns correlated with probiotic usage to improve responsiveness, using rigorous mechanistic studies in animal models or humans. Early-stage research applicants should consider a companion NOFO.

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