Simpler Grants.gov #PAR-25-185

NIH Grant for Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies

This opportunity is a research grant solicitation from the National Institutes of Health (NIH) focused on advancing the understanding of genetic variants linked to human congenital anomalies. - Government Buyer: - National Institutes of Health (NIH) - Products/Services Requested: - Research projects to screen, functionally validate, and characterize genomic variants associated with congenital anomalies, intellectual developmental disabilities, and inborn errors of metabolism - Use of public genomic databases such as dbGaP, Gabriella Miller Kids First Data Resource Portal, European Genome-Phenome Archive, and ClinGen - Application of in-silico tools, animal models, and in vitro systems for functional studies - Unique or Notable Requirements: - Emphasis on bridging the gap between genetic variant identification and functional impact assessment - Multi-pronged experimental approaches are encouraged - No specific products, part numbers, or OEMs are requested, as this is a research grant - Open to a wide range of eligible entities including educational institutions, nonprofits, government agencies, and businesses

Description

This funding opportunity from the National Institutes of Health aims to support research focused on the screening, functional validation, and characterization of genetic variants associated with human congenital anomalies. The initiative encourages the use of public genomic databases and various experimental approaches including in-silico tools, animal models, and in vitro systems to understand the functional effects of these variants on phenotypes. The goal is to bridge the gap between identifying genetic sequence variations and determining their impact on congenital defects. Eligible applicants include a wide range of educational institutions, nonprofits, government entities, and businesses.

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