Simpler Grants.gov #PAR-25-211

NIH Solicitation for Mechanistic Research on Precision Probiotic Therapies (R61/R33)

The National Institutes of Health (NIH) is seeking proposals for mechanistic research to advance precision probiotic therapies through a two-phase, milestone-driven R61/R33 award mechanism. - Government Buyer: - National Institutes of Health (NIH) - Products/Services Requested: - Mechanistic research to identify person-specific biological patterns influencing probiotic responses - Phase 1 (R61): Observational or secondary data analysis to characterize host features linked to variability in probiotic effects - Phase 2 (R33): Mechanistic studies in animal models or human subjects to test if identified patterns improve probiotic responsiveness - Unique/Notable Requirements: - Biphasic award structure (R61/R33) with transition contingent on milestone completion - Combined project duration not to exceed five years - Open to a broad range of applicants (educational institutions, nonprofits, government entities, small businesses) - No specific OEMs, vendors, or commercial products are referenced in this solicitation.

Description

This funding opportunity supports innovative mechanistic research to accelerate precision probiotic interventions using a milestone-driven, biphasic award mechanism (R61/R33). The research aims to characterize person-specific features affecting probiotic responses to identify subgroups of responders and improve clinical outcomes. The first phase (R61) focuses on identifying unique host biological patterns correlated with probiotic effects, while the second phase (R33) assesses these patterns in mechanistic studies in animal models or humans. The combined award duration should not exceed 5 years, with transition contingent on milestone completion.

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