Simpler Grants.gov #PAR-25-153

NCI Grant for Assay Development and Small Molecule Screening Research

This opportunity is a research grant from the National Cancer Institute (NCI) at the National Institutes of Health (NIH) to support the discovery and development of small molecule chemical probes, drugs, or immunomodulators. - Government Buyer: - National Institutes of Health (NIH) - National Cancer Institute (NCI) - Products/Services Requested: - Research services for assay development - High-throughput and moderate-throughput screening for small molecules - Hit validation, including secondary assays, cheminformatics, medicinal chemistry, and follow-up assays - Hit-to-lead optimization, including structure-activity relationship (SAR), ADME, PK, PD studies, and in vivo modeling - Unique/Notable Requirements: - Focus on discovery research for chemical probes or therapeutic agents - No clinical trials permitted under this grant - Open to a wide range of applicants, including universities, businesses, government agencies, nonprofits, and foreign entities - No specific OEMs or vendors are named, as this is a research grant, not a product procurement - Place of performance is the National Institutes of Health (NIH)

Description

The National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease targets for therapy or immunotherapy. The funding opportunity supports discovery research including assay development, screen implementation, hit validation, and hit-to-lead optimization. The research aims to identify validated hits relevant to health-related outcomes of participating NIH Institutes. Eligible applicants include a wide range of educational, business, government, nonprofit, and other organizations.

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