Simpler Grants.gov #PAR-25-051

NIH Blueprint Neurotherapeutics Network: Small Molecule Drug Discovery and Development for Nervous System Disorders

The National Institutes of Health (NIH) is seeking applications for the Blueprint Neurotherapeutics Network (BPN) program to support small molecule drug discovery and development for nervous system disorders. - Government Buyer: - National Institutes of Health (NIH) - Scope of Work: - Supports small molecule drug discovery and development projects targeting nervous system disorders - Applicants conduct disease- or target-specific assays and research in their own laboratories - Collaboration with NIH-funded consultants and contract research organizations (CROs) specializing in: - Medicinal chemistry - Pharmacokinetics - Toxicology - Formulations development - Chemical synthesis (including GMP) - Phase I clinical testing - Project Stages: - Projects may enter at Discovery or Development stage - Advancement through IND-enabling toxicology studies and Phase I clinical trials - Intellectual Property: - Awardee institutions retain IP rights for drug candidates developed - Eligibility: - Open to government entities, nonprofits, educational institutions, businesses, and other organizations - No specific OEMs, vendors, products, or part numbers are mentioned in the solicitation

Description

The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators to support small molecule drug discovery and development projects targeting nervous system disorders. Participants conduct disease- or target-specific assays and collaborate with NIH-funded consultants and contract research organizations specializing in medicinal chemistry, pharmacokinetics, toxicology, and clinical testing. Projects may enter at the Discovery or Development stage, advancing candidates through IND-enabling studies and Phase I clinical trials. Awardee institutions retain intellectual property rights for drug candidates developed under this program.

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