Simpler Grants.gov #PAR-25-145

NIH Grant for Research on Cancer Therapy-induced Adverse Effects and Interventions

This opportunity invites research organizations to apply for NIH funding to study and address adverse effects caused by cancer therapies. - Government Buyer: - National Institutes of Health (NIH) - Products/Services Requested: - Collaborative research projects focused on: - Clinical characterization of adverse sequelae from cancer therapies - Mechanistic studies to identify causes and develop interventions - Longitudinal clinical phenotyping and validation of clinical endpoints (e.g., biomarkers, imaging, patient-reported outcomes) - Development of mechanism-based therapeutic approaches to prevent or minimize long-term effects - OEMs and Vendors: - No specific OEMs or vendors are named, as this is a research grant opportunity - Unique or Notable Requirements: - Emphasis on mechanistic studies with translational endpoints - Projects should support future clinical trials by identifying and validating clinical endpoints - Wide eligibility: government, business, nonprofit, educational, tribal, and regional organizations may apply

Description

This Funding Opportunity Announcement (FOA) supports collaborative research projects aimed at addressing adverse sequelae of cancer therapies that persist as chronic comorbidities or delayed posttreatment effects. The research includes basic, translational, and clinical studies to identify mechanisms, clinically characterize adverse sequelae, and develop therapeutic approaches to prevent or minimize long-term effects. Projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping to identify and validate clinical endpoints for future clinical trials evaluating interventions.

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