Simpler Grants.gov #PAR-25-207

NIH Solicitation for Effectiveness Trials of Post-Acute Mental Health Interventions (R01 Clinical Trial Required)

The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), is seeking research services to evaluate the effectiveness of post-acute mental health interventions: - Government Buyer: - National Institutes of Health (NIH), National Institute of Mental Health (NIMH) - Products/Services Requested: - Clinical research services to conduct effectiveness trials of therapeutic and service delivery interventions for post-acute management of mental health conditions in youth, adults, and older adults - Focus areas include: - Consolidating and maintaining gains from initial treatment - Managing residual symptoms - Preventing relapse - Promoting adherence and appropriate service use - Statistically powered clinical trials are required; pilot trials are supported via a separate mechanism - OEMs and Vendors: - No specific OEMs or vendors are named, as this is a grant solicitation for research services - Unique or Notable Requirements: - Open to a wide range of eligible applicants, including government, nonprofit, educational, and tribal organizations - No product part numbers or specific equipment required; emphasis is on research methodology and clinical trial design - Place of Performance: - National Institutes of Health (NIH)

Description

The National Institute of Mental Health (NIMH) seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. The funding opportunity encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and service interventions matched to the stage of illness. The focus includes consolidating and maintaining gains from initial treatment, managing residual symptoms, preventing relapse, and promoting adherence and appropriate service use to optimize longer-term outcomes. This opportunity supports effectiveness trials that are statistically powered to provide definitive answers regarding intervention effectiveness, with pilot trials supported via a companion R34 mechanism.

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