Simpler Grants.gov #PAR-25-050

NIH Solicitation for Analytical Validation of Biomarkers for Neurological and Neuromuscular Disorders

This opportunity from the National Institutes of Health (NIH) seeks applications for cooperative agreements to analytically validate biomarker measurement methods for neurological and neuromuscular disorders. - Government Buyer: - National Institutes of Health (NIH) - Office: Extramural Research Programs in the Neurosciences and Neurological Disorders - OEMs and Vendors: - No specific Original Equipment Manufacturers (OEMs) or vendors are named in the solicitation - Products/Services Requested: - Analytical validation of biomarker detection methods - Activities include optimizing and evaluating accuracy, precision, reportable range, analytical sensitivity and specificity - Establishment of reference intervals and quality control procedures - Validation across multiple sites and operators is encouraged - Applicants must justify the unmet need for the biomarker and specify one or two intended contexts of use - Unique or Notable Requirements: - Multi-site applications are encouraged but not required - Open to a wide range of eligible applicants, including educational institutions, businesses, nonprofits, government entities, and certain tribal and regional organizations - No specific products, part numbers, or OEMs are identified

Description

This funding opportunity supports rigorous analytical validation of methods used for measuring biomarkers related to neurological and neuromuscular disorders for clinical trials or clinical practice. Applicants must justify the unmet need for the biomarker and specify one or two contexts of use. Activities include optimizing and evaluating accuracy, precision, reportable range, analytical sensitivity and specificity across multiple sites and operators, and establishing reference intervals and quality control procedures. Multi-site applications are encouraged but not required.

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