Simpler Grants.gov #PAR-25-038

NIH Research Grant Opportunity: Cellular and Molecular Biology of Complex Brain Disorders

This NIH funding opportunity supports research on the cellular and molecular biology of complex brain disorders: - Government Buyer: - National Institutes of Health (NIH) - Products/Services Requested: - Research grants (R01 mechanism) for studies on cellular and molecular mechanisms underlying complex brain disorders - Focus on high-confidence risk factors (polygenic, environmental) and their effects on neural function - Use of in vivo, in situ, or in vitro experimental paradigms, including model organisms and human cell-based assays - Generation and dissemination of data to federated resources (e.g., Gene Ontology, FAIR Data Informatics) - Unique/Notable Requirements: - Emphasis on fundamental biology and mechanistic understanding, not direct disease modeling - Data sharing to bridge disease risk, biological mechanisms, and therapeutic target identification - Clinical trials are not allowed - Broad eligibility: government, educational, nonprofit, business, tribal, and international organizations - No OEMs or commercial vendors are specified, as this is a research grant opportunity, not a product or service procurement.

Description

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, focusing on intracellular, transcellular, and circuit substrates of neural function. Studies may be hypothesis-generating or hypothesis-testing and can utilize in vivo, in situ, or in vitro experimental paradigms, including model organisms or human cell-based assays. The research should elucidate the neurobiological impact of individual or combined risk factors and disseminate findings to enrich common or federated data resources. This NOFO is intended for applications to further develop lines of inquiry where feasibility or proof-of-concept has been established.

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