Simpler Grants.gov #NOT-HD-25-006

NIH Funding for Genomic Curation Expert Panels for ClinGen

The National Institutes of Health (NIH), through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and several collaborating NIH Institutes and Centers, is preparing to fund Genomic Curation Expert Panels for the ClinGen resource. - Government Buyer: - NIH, led by NICHD, in collaboration with the National Eye Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute on Deafness and Other Communication Disorders, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, and National Cancer Institute - Products/Services Requested: - Establishment and operation of Genomic Curation Expert Panels - Panels will manually curate, review, and define the clinical relevance of genes and variants - Use of NHGRI ClinGen and NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure is mandatory - Unique/Notable Requirements: - Panels must follow established ClinGen and ClinVar protocols and utilize their systems - Focus on high-priority diseases or conditions to address gaps in genomic variant interpretation - Contribute to a centralized, authoritative public resource of expert-curated genetic data - OEMs and Vendors: - No specific commercial OEMs or vendors are named; required use of NHGRI ClinGen and NCBI ClinVar systems - Estimated Funding: - $880,000 total program funding, with four expected awards under cooperative agreements

Description

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), along with other NIH Institutes and Centers, intends to publish a Notice of Funding Opportunity to establish and continue Genomic Curation Expert Panels. These panels will manually curate, review, and define the clinical relevance of genes and variants as part of the NIH Clinical Genome Resource (ClinGen). The goal is to address the challenge of genomic variants of unknown significance by developing expert panels to select genes and variants associated with high priority diseases or conditions and determine their clinical significance. The panels must use NHGRI ClinGen and NCBI ClinVar procedures and tools to contribute to a centralized public resource of expert-curated genetic data.

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