Simpler Grants.gov #FOR-TR-27-003

NIH SPoT Initiative: Research Funding for Precision Drug Delivery Mechanisms

The National Institutes of Health (NIH), through the National Center for Advancing Translational Sciences (NCATS), is seeking research proposals under the Selective Precision Targeting (SPoT) initiative: - Purpose: Fund research to develop precise, on-target therapeutic drug delivery mechanisms to hard-to-reach locations in the human body using microphysiological systems (MPS) - Focus areas: - Targeted drug-delivery systems such as engineered nanoparticles, extracellular vesicles, and focused ultrasound - Delivery to challenging sites including the blood-brain barrier, tumors, and fibrotic tissue - Optimization of nanoparticle therapeutics, assessment of biodistribution and off-target effects, demonstration of functional cargo activity, and determination of optimal administration routes - No specific OEMs, vendors, or commercial products are named; this is a research grant opportunity - Eligible applicants: Educational institutions, nonprofits, government entities, and businesses - Funding details: - Total estimated funding: $1,500,000 - Up to five awards expected - Unique requirements: - Emphasis on innovative, translational research using MPS platforms - Proposals must address both delivery mechanism and functional demonstration of therapeutic activity - No product or service line items specified, as the opportunity is for research and development

Description

The National Center for Advancing Translational Science (NCATS) is initiating the Selective Precision Targeting (SPoT) program to develop precise therapeutic drug delivery mechanisms to hard-to-reach human body locations using microphysiological systems. The initiative focuses on optimizing nanoparticle targeting, assessing biodistribution and off-target effects, demonstrating functional cargo activity, and determining optimal administration routes. Target areas include the blood-brain barrier, central nervous system, placenta, retina, and tumors. The program supports various applicants including educational institutions, nonprofits, government entities, and businesses.

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