Simpler Grants.gov #FOR-HG-25-036

NHGRI Solicits Research Proposals for Innovative Molecular Technologies to Identify Genes Underlying Rare Genetic Disorders

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), is preparing to release a funding opportunity for research projects focused on innovative molecular technologies to identify genes or variants responsible for rare genetic disorders. - Government Buyer: - National Institutes of Health (NIH) - National Human Genome Research Institute (NHGRI) - Products/Services Requested: - Research services: Proof of concept studies using novel molecular technologies - Emphasis on approaches beyond traditional DNA sequencing - Technologies may include multi-omics, RNA-seq, methylation analysis, and other emerging methods - Pilot studies should demonstrate the potential of these technologies for gene/variant identification - Successful technologies may be considered for integration into the Technology Integration Center - OEMs and Vendors: - No specific OEMs or vendors are named in this opportunity - Unique/Notable Requirements: - Focus on rare genetic disorders and innovative, non-traditional molecular approaches - Open to a broad range of applicants: businesses, government, nonprofits, educational institutions - Funding instrument is a cooperative agreement (solicitation FOR-HG-25-036) - Technologies must be at the proof of concept stage and demonstrate clear potential for future integration

Description

The National Human Genome Research Institute (NHGRI) is soliciting applications for research on proof of concept studies that explore novel strategies for identifying genes or variants underlying rare genetic disorders using new and emerging molecular technologies. The initiative aims to move beyond DNA sequencing-based methods as an initial step, including pilot studies using technologies like multi-omics, RNA-seq, or methylation. Technologies showing potential will be integrated into the Technology Integration Center activities in later years. The NOFO is expected to be published in 2025 with an application due date in 2026, utilizing the U01 activity code.

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