Opportunity

Simpler Grants.gov #FOR-HG-25-027

NIH GREGoRi Technology Integration Center Research Funding Opportunity

Buyer

National Institutes of Health

Posted

June 06, 2025

Respond By

November 04, 2025

Identifier

FOR-HG-25-027

NAICS

541715, 541714

The National Human Genome Research Institute (NHGRI) at the National Institutes of Health (NIH) is announcing a forthcoming funding opportunity for the GREGoRi Technology Integration Center as part of the GREGoR program renewal. - Government Buyer: - National Institutes of Health (NIH) - National Human Genome Research Institute (NHGRI) - Purpose and Scope: - Establish the GREGoRi Technology Integration Center to advance rare disease diagnosis - Develop standards, best practices, and new molecular technologies for rare disease research - Create a multidimensional dataset to support novel diagnostic tools - Funding Details: - Cooperative agreement (U01 mechanism) - Estimated total program funding: $3,000,000 for one award - Eligibility: - Open to nonprofits, small businesses, higher education institutions, and tribal organizations - Products/Services Requested: - No specific OEMs, vendors, or commercial products identified (research grant opportunity) - Focus on research, technology development, and data integration - Unique Requirements: - Emphasis on standards development and integration of new molecular technologies - Creation of a comprehensive dataset for rare disease diagnosis - Clinical trials are optional - No specific part numbers, quantities, or commercial products are listed, as this is a research funding opportunity.

Description

The National Human Genome Research Institute (NHGRI) is issuing a Notice of Funding Opportunity (NOFO) to renew the GREGoR program with a new initiative called GREGoRi. This initiative aims to accelerate rare disease diagnosis by developing new tools, molecular technologies, and analytical approaches to identify causal genes or variants. The GREGoRi Technology Integration Center will establish standards and best practices for applying emerging molecular methods in rare disease diagnosis and produce a multidimensional dataset for developing and benchmarking novel diagnostic tools. The NOFO is expected to be published in 2025 with applications due in 2026, utilizing the U01 activity code.

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