Simpler Grants.gov #FOR-HG-25-018

NIH Solicits Research Applications for Systematic Characterization of Genomic Variation

The National Institutes of Health (NIH), through the National Human Genome Research Institute (NHGRI), is inviting research applications focused on understanding genomic variation and its impact on genome function and phenotype. - Government Buyer: - National Institutes of Health (NIH) - National Human Genome Research Institute (NHGRI) - Scope of Work: - Systematic characterization of genomic variation - Assessment of individual variant effects on genome function and phenotype - Use of high-throughput methods to perturb variants or elements - Data collection on effects in DNA, RNA, or protein-coding elements - Development of robust, reproducible, and portable data processing pipelines - Collaboration within the Impact of Genomic Variation on Function (IGVF) Consortium - Coordination of assays, variants, cell types, and analysis strategies - Ensuring accessibility and sharing of consortium resources - Products/Services Requested: - Research services (no specific products, part numbers, or OEMs listed) - Unique Requirements: - Participation in a multi-institutional consortium (IGVF) - Emphasis on data sharing, reproducibility, and collaborative analysis - Open to a wide range of eligible applicants (small businesses, government, nonprofits, educational institutions) - Estimated funding: $3,000,000 (forecasted) - No specific OEMs or vendors are mentioned, as this is a research grant opportunity.

Description

The National Human Genome Research Institute (NHGRI) is soliciting applications for research to characterize genomic variation and assess the impact of individual variants on genome function. The research will involve systematically perturbing variants or elements using high-throughput methods, collecting data on variant effects on molecular, cellular, or organismal phenotypes, and developing robust data processing pipelines. Funded centers will join the Impact of Genomic Variation on Function (IGVF) Consortium and collaborate to ensure resource accessibility and coordinate assays, variants, and cell types. This initiative aims to promote collaboration and develop shared analysis strategies to meet consortium goals.

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