SAM #75N98026Q00243

Procurement of Human Putative Humanin Peptide (MT-RNR2) ELISA Kits for NIH/NIA HANDLS Study

The National Institutes of Health (NIH), National Institute on Aging (NIA), is seeking to procure Human Putative humanin peptide (MT-RNR2) ELISA kits to support the HANDLS longitudinal study on aging and chronic diseases. - Government Buyer: - National Institutes of Health (NIH) - National Institute on Aging (NIA) - Products/Services Requested: - Forty-nine (49) Human Putative humanin peptide (MT-RNR2) ELISA kits - Part number: CSB-EL015084HU - 96-well format, sensitivity <7 pg/ml, requires <50 ul serum per assay - Must be compatible with SpectraMax M2 Microplate Reader - Used for quantitative measurement of humanin in human serum - Unique/Notable Requirements: - Brand name or equal requirement to ensure continuity and comparability with previous research - Kits must be suitable for ongoing longitudinal studies on aging and age-related diseases - Delivery Location: - NIH/NIDA, 251 Bayview Blvd STE 100, BRC Bldg. RM 06C232, Baltimore, MD 21224 - Period of Performance: - 12 months from award; no option years specified - No specific OEMs are named, but the requirement is for the CSB-EL015084HU kit or equivalent.

Description

COMBINED SYNOPSIS / SOLICITATION - COMPETITIVE

Title: Human Putative Humanin Peptide (MT-RNR2) ELISA Kits

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested, and a separate written solicitation will not be issued.

The solicitation number is 75N98026Q00243, and the solicitation is issued as a request for quotation (RFQ).

Simplified Acquisition Procedures and FAR Part 12—Acquisition of Commercial Items—are applicable, and the total value is not expected to exceed the simplified acquisition threshold. A fixed-price purchase order is contemplated for this requirement.

The National Institute of Aging (NIA), Investigators in the HANDLS study, require data on circulating humanin (MT-RNR2) levels to support an ongoing longitudinal study. This data will expand current research on how circulating factors influence age-related chronic diseases. Humanin has anti-apoptotic, metabolic, and neuroprotective properties and has been associated with lifespan. It is essential to quantitatively measure serum levels of humanin in HANDLS participants to understand its role in aging and age-related diseases, including type 2 diabetes. The government requires specific ELISA kits because it has the necessary expertise, equipment, and resources to perform the work using these kits at our Institute.

Attachment 1 – Purchase Description for additional details.

The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2025-05, dated 08-07-2025.

The North American Industry Classification System (NAICS) Code for this procurement is 325414—Biological Product (Except Diagnostic) Manufacturing.

Line Items: Through this procurement, NIA anticipates a single award, firm fixed-price purchase order for a total of forty-nine (49) Human Putative Humanin Peptide (MT-RNR2) ELISA Kits.

(Lowest Price Technically Acceptable) as described in Attachment 1 – Purchase Description

Below is a table containing the line item numbers and descriptions of the brand name or equal requirement for the anticipated award:

Line No. Description 1 Human Putative Humanin Peptide (MT-RNR2) ELISA. SIZE 96T. QTY of 49.

Description Requirement: Humanin (MT-RNR2) is a small, mitochondria-derived peptide that has attracted significant scientific interest due to its cytoprotective and anti-apoptotic properties. Humanin has been associated with aging and age-related chronic diseases, including type 2 diabetes, neurodegenerative diseases, and cardiovascular disease. To gain insight into its role in these processes in human cohorts, we will quantitatively measure circulating humanin levels using ELISA kits. Serum samples from HANDLS participants are limited in quantity (

Salient Characteristics:

Human Humanin ELISA kit ELISA technology 96 well format One kit assays humanin in 96 samples (including standards) Measures humanin from human serum Sensitivity to measure humanin at <7 pg/ml Required serum volume <50 ul Compatible with SpectraMax M2 Microplate Reader For research continuity, results must be comparable to previous data using the same kit Data generated must be directly comparable to previously published results in human aging cohorts

Period of Performance

12 months from the date of award.

Option Quantities

N/A

Shipping Instructions

NIH/NIDA

251 Bayview Blvd STE 100

BRC Bldg. RM 06C232

Baltimore, MD 21224

Delivery

Within 2 weeks of receipt and acceptance of award.

Payment

Net 30

Statutory Authority:

This notice is a Combined Synopsis/Solicitation for commercial items using Simplified Acquisition Procedures. This acquisition will be made in accordance with FAR Subpart 12.6, “Streamlined Procedures for Evaluation and Solicitation for Commercial Items,” as applicable, and supplemented with additional information in this notice. This is the only solicitation; quotes are requested.

Closing Statement:

Responses must include sufficient information to demonstrate the bona-fide capabilities of providing the product. The response should include: unit price, list price, shipping and handling costs, delivery days after award, delivery terms, prompt payment discount terms, F.O.B. point, product or catalog number(s), description, and any other relevant information. The government intends to award a firm fixed-price purchase order based on brand name requirements, salient characteristics, price, and delivery.

Terms and Conditions:

The vendor accepts the following terms by submitting a quote:

FAR 52.212-1 Instructions to Offerors—Commercial Items (SEP 2023) FAR 52.212-3 Offerors Representations and Certifications—Commercial Items (OCT 2025) FAR 52.204-7 System for Award Management (NOV 2024) Offerors must complete annual representations and certifications at http://www.sam.gov/ (including FAR 52.209-2) FAR 52.203-18 Prohibition on Contracting with Entities Requiring Certain Internal Confidentiality Agreements (JAN 2017) FAR 52.204-26 Covered Telecommunications Equipment or Services—Representation (OCT 2020) FAR 52.211-6 Brand Name or Equal (AUG 1999)

The following FAR clauses apply:

FAR 52.212-4 Contract Terms and Conditions—Commercial Items (NOV 2023) FAR 52.212.5 Contract Terms and Conditions—Required Statutes or Executive Orders—Commercial Items (JAN 2025) (see Attachment 2) FAR 52.232-40 Providing Accelerated Payments to Small Business Subcontractors (MAR 2023) FAR 52.204-13 System for Award Management Maintenance (OCT 2018) FAR 52.204-25 Prohibition on Contracting for Certain Telecommunications and Video Surveillance Services or Equipment (NOV 2021) HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (DEC 2015) FAR 52.252-2 -- Clauses Incorporated by Reference (FEB 1998)

These clauses are incorporated by reference, with full text available upon request or electronically at http://farsite.hill.af.mil/vffara.htm.

By submitting an offer, the vendor acknowledges the requirement to be registered in the System for Award Management (SAM) database prior to award, during performance, and through final payment. Registration is at http://www.sam.gov/.

All responses must be received by 05/02/2026 @ 4:00 PM EST and must reference the solicitation number 75N98026Q00243. Responses should be submitted electronically to johnsonjr@mail.nih.gov. Late submissions will be handled according to FAR 52.212-1(f). All responsible sources may submit an offer for consideration.

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