SAM #75N98026Q00221

Acquisition of Bioruptor Pico Sonication Device for Neurodegenerative Disease Research

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is seeking to acquire a specialized sonication device for neurodegenerative disease research. - Government Buyer: - National Institutes of Health (NIH) - Sub-agency: National Heart, Lung, and Blood Institute (NHLBI) - Office: Laboratory of Protein Conformation and Dynamics - OEMs and Vendors: - Hologic Sales and Service, LLC (exclusive U.S. distributor for the device) - Products/Services Requested: - Bioruptor Pico Sonication Device (or equivalent) - Quantity: 1 unit - Key features required: - Indirect (bath-based) sonication without direct probe contact - Processing of samples in sealed tubes - Adaptive cavitation technology for controlled and reproducible sonication - Continuous sample rotation - Integrated temperature control - Compatibility with small sample volumes (20 µL to 2 mL) - Ability to process multiple samples simultaneously - Validated reproducibility for pre-formed fibril (PFF) preparation - Unique or Notable Requirements: - Device must enable highly controlled, reproducible sonication for standardized preparation of PFFs used in amyloid seeding experiments - Delivery required within 2 to 6 weeks after award - Hologic Sales and Service, LLC is identified as the sole responsible source and exclusive U.S. distributor - Place of Performance and Delivery: - Laboratory of Protein Conformation and Dynamics, 50 South Dr Rm 3512, Bethesda, MD 20894

Description

The National Heart, Lung, and Blood Institute (NHLBI) intends to award a sole source purchase order to Hologic Sales and Service, LLC for the acquisition of a sonication device to support amyloid seeding experiments. The required system must provide highly controlled, reproducible sonication of small-volume biological samples to enable standardized preparation of pre-formed fibrils (PFFs), which are critical for ongoing research into neurodegenerative diseases. This notice of intent is not a request for competitive quotations; however, interested parties may submit a capability statement demonstrating their ability to meet all minimum technical requirements, including controlled cavitation, sealed-tube processing, continuous sample rotation, and validated reproducibility for PFF generation.

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