SAM #PCA-NIA-02375

This opportunity from NIH OLAO seeks specialized DNA and RNA extraction services for mouse samples, emphasizing scientific consistency and quality control. - NIH OLAO requires: - Custom DNA extraction from mouse whole blood (white cell pellets) - Custom DNA and RNA extraction from mouse organs (lung, spleen, heart, kidney, brain, liver) - Agilent RNA quality control for organ samples - Consistency in extraction chemistry, instrumentation, workflow, and QC thresholds is critical - Prevents batch effects that could distort methylation signatures, gene expression profiles, and sequencing quality - No specific OEMs or vendors are named - Place of performance is Bethesda, Maryland - Services must be compatible with previous datasets for scientific integrity

CUSTOM DNA Extraction from mouse whole blood (white cell pellets)

CUSTOM DNA and RNA Extraction from mouse organs (lung, spleen, heart, kidney, brain, liver) + Agilent RNA QC

would introduce unavoidable differences in extraction chemistry, instrumentation, workflow, and QC thresholds, generating batch effects that would distort methylation signatures, gene expression profiles, and sequencing quality. These discrepancies cannot be corrected computationally and would render the new data scientifically incompatible with the previously generated dataset, undermining the validity of the combined analysis and jeopardizing both the submitted manuscript and the continuation study