Award
NIH Reporter #1R21AI193347-01A1
Dissecting the mechanisms driving isoprenoid-dependent immune dysregulation in pathology of mevalonate kinase deficiency
Recipient
Washington University
Award Amount
$233,250.00
Ceiling
$233,250.00
Awarded
August 11, 2026
Identifier
1R21AI193347-01A1
The project studies mechanisms linking isoprenoid deficiency to immune dysregulation in mevalonate kinase deficiency and explores whether geranylgeraniol supplementation may inform treatment approaches.
Description
Research project investigating how isoprenoid deficiency affects immune function and B-cell differentiation in mevalonate kinase deficiency, including the potential effects of metabolite supplementation.