# NIH Reporter #1R21AI193347-01A1

Dissecting the mechanisms driving isoprenoid-dependent immune dysregulation in pathology of mevalonate kinase deficiency

**Recipient:** Washington University

**Award Amount:** $233,250.00
**Ceiling:** $233,250.00

**Awarded:** August 11, 2026

**Identifier:** 1R21AI193347-01A1

The project studies mechanisms linking isoprenoid deficiency to immune dysregulation in mevalonate kinase deficiency and explores whether geranylgeraniol supplementation may inform treatment approaches.

### Description

Research project investigating how isoprenoid deficiency affects immune function and B-cell differentiation in mevalonate kinase deficiency, including the potential effects of metabolite supplementation.

[View original record](https://reporter.nih.gov/search/47CiHD0bJ0u2LtDABS0zbg/project-details/11454716)