Award
NIH Reporter #5R01DK114103-08
Keeping fat out of muscle - Role of Branched Amino AcidsAmino Acids in Insulin Resistance
Recipient
University of Pennsylvania
Award Amount
$705,907.00
Ceiling
$705,907.00
Awarded
August 19, 2026
Identifier
5R01DK114103-08
The project studies whether insulin promotes branched-chain amino acid catabolism in smooth muscle cells, which may improve vasodilation and glucose tolerance. The award supports research on mechanisms linking this pathway to insulin resistance and diabetes.
Description
NIH-funded project investigating how branched-chain amino acid catabolism in smooth muscle cells may regulate vascular reactivity, glucose tolerance, and insulin resistance, using genetic mouse models, vascular physiology assays, glucose clamps, and human studies.