# NIH Reporter #5R01DK114103-08

Keeping fat out of muscle - Role of Branched Amino AcidsAmino Acids in Insulin Resistance

**Recipient:** University of Pennsylvania

**Award Amount:** $705,907.00
**Ceiling:** $705,907.00

**Awarded:** August 19, 2026

**Identifier:** 5R01DK114103-08

The project studies whether insulin promotes branched-chain amino acid catabolism in smooth muscle cells, which may improve vasodilation and glucose tolerance. The award supports research on mechanisms linking this pathway to insulin resistance and diabetes.

### Description

NIH-funded project investigating how branched-chain amino acid catabolism in smooth muscle cells may regulate vascular reactivity, glucose tolerance, and insulin resistance, using genetic mouse models, vascular physiology assays, glucose clamps, and human studies.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11384567)