Award
NIH Reporter #1R01HD120423-01
Impact of maturation on the pharmacokinetic and physiologic response to furosemide in very preterm infants (IMPPROVE-furosemide)
Recipient
Children's Hospital of Philadelphia
Award Amount
$3,203,539.00
Ceiling
$3,203,539.00
Awarded
September 10, 2026
Identifier
1R01HD120423-01
The award funds a study to understand how maturation affects furosemide clearance and physiological response in very preterm infants, aiming to improve dosing strategies and inform future clinical trials.
Description
This project addresses a critical knowledge gap in neonatal pharmacology by studying how furosemide clearance changes as very preterm infants mature. It involves a prospective longitudinal observational cohort study measuring blood concentrations and physiologic responses to inform dosing adjustments and guide clinical trials.