# NIH Reporter #1R01HD120423-01

Impact of maturation on the pharmacokinetic and physiologic response to furosemide in very preterm infants (IMPPROVE-furosemide)

**Recipient:** Children's Hospital of Philadelphia

**Award Amount:** $3,203,539.00
**Ceiling:** $3,203,539.00

**Awarded:** September 10, 2026

**Identifier:** 1R01HD120423-01

The award funds a study to understand how maturation affects furosemide clearance and physiological response in very preterm infants, aiming to improve dosing strategies and inform future clinical trials.

### Description

This project addresses a critical knowledge gap in neonatal pharmacology by studying how furosemide clearance changes as very preterm infants mature. It involves a prospective longitudinal observational cohort study measuring blood concentrations and physiologic responses to inform dosing adjustments and guide clinical trials.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11272563)