Award
NIH Reporter #1R21HD123018-01
A Forward Genetic Screen to Identify Genes Involved in Left-Right Patterning
Recipient
Princeton University
Award Amount
$451,000.00
Ceiling
$451,000.00
Awarded
September 10, 2026
Identifier
1R21HD123018-01
The award funds a research project at Princeton University to identify genes involved in left-right patterning using a forward genetic screen in zebrafish. The project is innovative and high-risk, aiming to uncover new genetic factors affecting embryonic asymmetry and congenital heart defects.
Description
This project aims to generate a resource of zebrafish mutants affecting left-right patterning through a forward genetic mutant screen. It will clone ten mutants using a new mapping pipeline developed by collaborators, applying innovative next-generation sequencing techniques. The project is high-risk but potentially groundbreaking, providing new molecular insights into left-right patterning mechanisms and candidates for congenital heart defects and heterotaxy syndromes.