# NIH Reporter #1R21HD123018-01

A Forward Genetic Screen to Identify Genes Involved in Left-Right Patterning

**Recipient:** Princeton University

**Award Amount:** $451,000.00
**Ceiling:** $451,000.00

**Awarded:** September 10, 2026

**Identifier:** 1R21HD123018-01

The award funds a research project at Princeton University to identify genes involved in left-right patterning using a forward genetic screen in zebrafish. The project is innovative and high-risk, aiming to uncover new genetic factors affecting embryonic asymmetry and congenital heart defects.

### Description

This project aims to generate a resource of zebrafish mutants affecting left-right patterning through a forward genetic mutant screen. It will clone ten mutants using a new mapping pipeline developed by collaborators, applying innovative next-generation sequencing techniques. The project is high-risk but potentially groundbreaking, providing new molecular insights into left-right patterning mechanisms and candidates for congenital heart defects and heterotaxy syndromes.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11438936)