Award
NIH Reporter #5R01ES034753-05
Environmental Pollutants and AHR pathway in Uterine Leiomyoma
Recipient
Northwestern University
Award Amount
$600,923.00
Ceiling
$600,923.00
Awarded
November 05, 2026
Identifier
5R01ES034753-05
The project studies whether MED12 mutations and exposure to the endocrine-disrupting chemical DEHP promote uterine fibroid growth through tryptophan metabolism, kynurenine production, and AHR activation. It aims to define the pathway's role in tumorigenesis and assess potential therapeutic directions.
Description
Research project investigating the role of the tryptophan-kynurenine-aryl hydrocarbon receptor (AHR) pathway and the effects of DEHP exposure in uterine leiomyoma growth.