# NIH Reporter #5R01ES034753-05

Environmental Pollutants and AHR pathway in Uterine Leiomyoma

**Recipient:** Northwestern University

**Award Amount:** $600,923.00
**Ceiling:** $600,923.00

**Awarded:** November 05, 2026

**Identifier:** 5R01ES034753-05

The project studies whether MED12 mutations and exposure to the endocrine-disrupting chemical DEHP promote uterine fibroid growth through tryptophan metabolism, kynurenine production, and AHR activation. It aims to define the pathway's role in tumorigenesis and assess potential therapeutic directions.

### Description

Research project investigating the role of the tryptophan-kynurenine-aryl hydrocarbon receptor (AHR) pathway and the effects of DEHP exposure in uterine leiomyoma growth.

[View original record](https://reporter.nih.gov/search/a_XEnEpPR0i-06zXlbqcPw/project-details/11472699)