Award
NIH Reporter #1R21NS147051-01A1
Peripheral Immune Dysfunctions and their Role in ALS
Recipient
Washington University, Pathology
Award Amount
$427,625.00
Ceiling
$427,625.00
Awarded
September 17, 2026
Identifier
1R21NS147051-01A1
NIH funding supports research into how immune dysfunction may influence ALS progression, comparing human ALS samples and a mouse model to identify shared immune pathways and potential therapeutic targets.
Description
The project will investigate peripheral and CNS-associated immune dysfunctions in ALS4 and sporadic ALS patients using single-cell RNA and T cell receptor sequencing and proteomic profiling, and assess related immune alterations in a mouse model of TDP-43 mislocalization. It aims to identify immune signatures and candidate biomarkers or therapeutic targets.