# NIH Reporter #1R21NS147051-01A1

Peripheral Immune Dysfunctions and their Role in ALS

**Recipient:** Washington University, Pathology

**Award Amount:** $427,625.00
**Ceiling:** $427,625.00

**Awarded:** September 17, 2026

**Identifier:** 1R21NS147051-01A1

NIH funding supports research into how immune dysfunction may influence ALS progression, comparing human ALS samples and a mouse model to identify shared immune pathways and potential therapeutic targets.

### Description

The project will investigate peripheral and CNS-associated immune dysfunctions in ALS4 and sporadic ALS patients using single-cell RNA and T cell receptor sequencing and proteomic profiling, and assess related immune alterations in a mouse model of TDP-43 mislocalization. It aims to identify immune signatures and candidate biomarkers or therapeutic targets.

[View original record](https://reporter.nih.gov/search/0ftClcwKYUOEq8QKPKx2lA/project-details/11453136)