Award
NIH Reporter #5R01HL181370-02
Erythroblastic island macrophages in normal erythropoiesis and disordered erythropoiesis in polycythemia vera
Recipient
New York Blood Center, Rye, NY, United States
Award Amount
$785,595.00
Ceiling
$785,595.00
Awarded
May 05, 2026
Identifier
5R01HL181370-02
Research project funded by NHLBI to study the role of macrophages in erythropoiesis and the impact of JAK2 mutations in polycythemia vera, aiming to identify therapeutic targets for anemia and erythrocytosis.
Description
This project investigates how macrophages support erythropoiesis via EPO/EPOR signaling and how JAK2 mutations contribute to polycythemia vera. The study aims to define mechanisms of normal and disordered erythropoiesis, explore therapeutic targets, and improve understanding of anemia and erythrocytosis.