# NIH Reporter #5R01HL181370-02

Erythroblastic island macrophages in normal erythropoiesis and disordered erythropoiesis in polycythemia vera

**Recipient:** New York Blood Center, Rye, NY, United States

**Award Amount:** $785,595.00
**Ceiling:** $785,595.00

**Awarded:** May 05, 2026

**Identifier:** 5R01HL181370-02

Research project funded by NHLBI to study the role of macrophages in erythropoiesis and the impact of JAK2 mutations in polycythemia vera, aiming to identify therapeutic targets for anemia and erythrocytosis.

### Description

This project investigates how macrophages support erythropoiesis via EPO/EPOR signaling and how JAK2 mutations contribute to polycythemia vera. The study aims to define mechanisms of normal and disordered erythropoiesis, explore therapeutic targets, and improve understanding of anemia and erythrocytosis.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11378743)