Award
NIH Reporter #1R21AR087046-01A1
MafB mutations in Multicentric Carpo-Tarsal Osteolysis (MCTO): Multi-omic Exploration of the Mechanisms Involved in Skeletal Osteolysis in a Mouse MCTO Model
Recipient
Harvard Medical School
Award Amount
$395,038.00
Ceiling
$395,038.00
Awarded
September 17, 2026
Identifier
1R21AR087046-01A1
NIAMS awarded Harvard Medical School funding to study the mechanisms of skeletal osteolysis in a mouse model of Multicentric Carpo-Tarsal Osteolysis, with the goal of informing potential therapeutic approaches.
Description
The project will use a MafB knock-in mouse model to investigate cellular and microenvironmental changes associated with MCTO mutations, using transcriptomic and proteomic studies to identify altered gene profiles and cytokine-signaling pathways.