# NIH Reporter #1R21AR087046-01A1

MafB mutations in Multicentric Carpo-Tarsal Osteolysis (MCTO): Multi-omic Exploration of the Mechanisms Involved in Skeletal Osteolysis in a Mouse MCTO Model

**Recipient:** Harvard Medical School

**Award Amount:** $395,038.00
**Ceiling:** $395,038.00

**Awarded:** September 17, 2026

**Identifier:** 1R21AR087046-01A1

NIAMS awarded Harvard Medical School funding to study the mechanisms of skeletal osteolysis in a mouse model of Multicentric Carpo-Tarsal Osteolysis, with the goal of informing potential therapeutic approaches.

### Description

The project will use a MafB knock-in mouse model to investigate cellular and microenvironmental changes associated with MCTO mutations, using transcriptomic and proteomic studies to identify altered gene profiles and cytokine-signaling pathways.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11452238)