NIH Reporter #3R01AI184285-03S1

Early interventions at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responses

This NIH-funded project investigates early intervention with broadly neutralizing antibodies at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responses, aiming to inform future HIV cure strategies.

Description

Delivery of broadly neutralizing antibodies against HIV at the time of antiretroviral therapy initiation can enable immune-mediated control of HIV infection in some people living with HIV after therapy is stopped. This project aims to perform mechanistic and discovery-based strategies to understand how this therapeutic strategy affects the long-lived HIV reservoir and improves HIV-specific immune responses in some individuals but not others. The research will focus on defining phenotypic, functional, and transcriptomic features of adaptive T cell immune responses modulated by broadly neutralizing antibody treatment, understanding how the HIV reservoir is differentially modulated after prolonged ART, and assessing the ability of CD8+ T cells to mediate viral control using a humanized mouse model.

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