Award
NIH Reporter #5R01AI134834-07
Gene regulation mechanisms involving the inactive X in B cells during lupus disease
Recipient
University of Pennsylvania
Award Amount
$609,688.00
Ceiling
$609,688.00
Awarded
August 24, 2026
Identifier
5R01AI134834-07
The project examines how chronic type I interferon inflammation may disrupt inactive X chromosome regulation in B cells and contribute to female-biased lupus.
Description
Investigates how chronic inflammation from elevated type I interferons affects X-chromosome inactivation, epigenetic modifications, chromosome organization, and X-linked gene expression in B cells in lupus disease.