# NIH Reporter #5R01AI134834-07

Gene regulation mechanisms involving the inactive X in B cells during lupus disease

**Recipient:** University of Pennsylvania

**Award Amount:** $609,688.00
**Ceiling:** $609,688.00

**Awarded:** August 24, 2026

**Identifier:** 5R01AI134834-07

The project examines how chronic type I interferon inflammation may disrupt inactive X chromosome regulation in B cells and contribute to female-biased lupus.

### Description

Investigates how chronic inflammation from elevated type I interferons affects X-chromosome inactivation, epigenetic modifications, chromosome organization, and X-linked gene expression in B cells in lupus disease.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11406130)