Award
NIH Reporter #1R21DA064020-01A1
THC exposure and inhibitory circuit plasticity in the neocortex
Recipient
Carnegie-Mellon University
Award Amount
$191,250.00
Ceiling
$191,250.00
Awarded
September 02, 2026
Identifier
1R21DA064020-01A1
NIH-funded research at Carnegie-Mellon University will investigate how acute and chronic THC exposure affects neocortical inhibitory neuron activity and synaptic connections.
Description
The project examines acute and long-term effects of Δ9-tetrahydrocannabinol (THC) on the activity and synaptic properties of VIP- and SST-expressing neocortical interneurons, using THC-exposed adolescent mice, in vivo calcium imaging, and fluorescence-based synapse analysis.