# NIH Reporter #1R21DA064020-01A1

THC exposure and inhibitory circuit plasticity in the neocortex

**Recipient:** Carnegie-Mellon University

**Award Amount:** $191,250.00
**Ceiling:** $191,250.00

**Awarded:** September 02, 2026

**Identifier:** 1R21DA064020-01A1

NIH-funded research at Carnegie-Mellon University will investigate how acute and chronic THC exposure affects neocortical inhibitory neuron activity and synaptic connections.

### Description

The project examines acute and long-term effects of Δ9-tetrahydrocannabinol (THC) on the activity and synaptic properties of VIP- and SST-expressing neocortical interneurons, using THC-exposed adolescent mice, in vivo calcium imaging, and fluorescence-based synapse analysis.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11381288)