Award
NIH Reporter #5R37AI195421-02
Therapeutic vaccination to boost autologous neutralizing antibodies for ART free HIV Control
Recipient
University of Pennsylvania
Award Amount
$881,967.00
Ceiling
$881,967.00
Awarded
July 14, 2026
Identifier
5R37AI195421-02
The NIH-funded project investigates whether personalized therapeutic vaccination can enhance existing HIV-neutralizing antibody responses and support ART-free viral control.
Description
A project testing personalized mRNA-LNP-delivered Env immunogens to boost existing autologous neutralizing antibody responses and promote HIV viral control without antiretroviral therapy. The study compares personalized immunogens, germline-targeting immunogens, and ART alone in rhesus macaques.