# NIH Reporter #5R37AI195421-02

Therapeutic vaccination to boost autologous neutralizing antibodies for ART free HIV Control

**Recipient:** University of Pennsylvania

**Award Amount:** $881,967.00
**Ceiling:** $881,967.00

**Awarded:** July 14, 2026

**Identifier:** 5R37AI195421-02

The NIH-funded project investigates whether personalized therapeutic vaccination can enhance existing HIV-neutralizing antibody responses and support ART-free viral control.

### Description

A project testing personalized mRNA-LNP-delivered Env immunogens to boost existing autologous neutralizing antibody responses and promote HIV viral control without antiretroviral therapy. The study compares personalized immunogens, germline-targeting immunogens, and ART alone in rhesus macaques.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11395623)