Award
NIH Reporter #5K99HL181288-02
Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$169,020.00
Ceiling
$169,020.00
Awarded
September 17, 2026
Identifier
5K99HL181288-02
Research project funded by the National Heart Lung and Blood Institute to study mechanical memory in cardiomyocytes through molecular and epigenetic analysis, with the goal of understanding and mitigating myocardial dysfunction.
Description
This project aims to understand how mechanical forces influence nuclear signaling and epigenetic regulation in cardiomyocytes, focusing on the phenomenon of mechanical memory (MM). The research involves studying the molecular pathways, epigenetic landscapes, and DNA damage responses associated with extracellular stiffening and their implications for long-term heart health.