# NIH Reporter #5K99HL181288-02

Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes

**Recipient:** University of Pennsylvania, Philadelphia, PA, United States

**Award Amount:** $169,020.00
**Ceiling:** $169,020.00

**Awarded:** September 17, 2026

**Identifier:** 5K99HL181288-02

Research project funded by the National Heart Lung and Blood Institute to study mechanical memory in cardiomyocytes through molecular and epigenetic analysis, with the goal of understanding and mitigating myocardial dysfunction.

### Description

This project aims to understand how mechanical forces influence nuclear signaling and epigenetic regulation in cardiomyocytes, focusing on the phenomenon of mechanical memory (MM). The research involves studying the molecular pathways, epigenetic landscapes, and DNA damage responses associated with extracellular stiffening and their implications for long-term heart health.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11418997)